The maintenance of a low NADH/NAD+ ratio might be achieved by preserving the complex I activity from the inhibitory effects of cardio lipin peroxidation and sustained glutathionylation, for which the maintenance of high GSH/GSS ratios would be beneficial. The resultant increase in NAD+ levels might impact favorably insulin resistance in diabetes and obesity by decreasing …
Recent studies have revealed that decline in cellular nicotinamide adenine dinucleotide (NAD+ ) levels causes aging-related disorders and therapeutic approaches increasing cellular NAD+ prevent these disorders in animal models. The administration of nicotinamide mononucleotide (NMN) has been shown to mitigate aging-related dysfunctions. However, the safety of NMN in humans have remained unclear. We, therefore, conducted …
Abstract Inherited methylation disorders are a group of rarely reported, probably largely underdiagnosed disorders affecting transmethylation processes in the metabolic pathway between methionine and homocysteine. These are methionine adenosyltransferase I/III, glycine N-methyltransferase, S adenosylhomocysteine hydrolase and adenosine kinase defi ciencies. This paper provides the first consensus recommenda tions for the diagnosis and management of methylation …
