NAD+

Nadiia Kryzhanovska, MD, PhD, reviews the literature surrounding NAD+ as a potential therapy to tackle the onset of ageing. The Magic of NAD+: A Major Player in Anti-Ageing.   In 2015, KAEBERLEIN ET AL. described the primary preventive methods against age-associated diseases1. They included dietary restriction, exercise, mechanistic targets for rapamycin (mTOR) inhibitors, metformin and …

The Magic of NAD+: A Major Player in Anti-Ageing. Read More »

While mitochondrial dysfunction is emerging as key in Parkinson’s disease (PD), a central question remains whether mitochondria are actual disease drivers and whether boosting mitochondrial biogenesis and function ameliorates pathology. We address these questions using patient-derived induced pluripotent stem cells and GBA-PD), the most common PD genetic risk. Patient neurons display stress responses, mitochondrial demise, and changes in NAD+ metabolism. …

The NAD+ Precursor Nicotinamide Riboside Rescues
Mitochondrial Defects and Neuronal Loss in iPSC
and Fly Models of Parkinson’s Disease Read More »

The maintenance of a low NADH/NAD+ ratio might be achieved by preserving the complex I activity from the inhibitory effects of cardio lipin peroxidation and sustained glutathionylation, for which the maintenance of high GSH/GSS ratios would be beneficial. The resultant increase in NAD+ levels might impact favorably insulin resistance in diabetes and obesity by decreasing …

NAD+ and insulin resistance Read More »

Recent studies have revealed that decline in cellular nicotinamide adenine dinucleotide (NAD+ ) levels causes aging-related disorders and therapeutic approaches increasing cellular NAD+ prevent these disorders in animal models. The administration of nicotinamide mononucleotide (NMN) has been shown to mitigate aging-related dysfunctions. However, the safety of NMN in humans have remained unclear. We, therefore, conducted …

About NAD+ Read More »