S-adenosyl methionine (SAMe) A high-quality Cochrane review of the effectiveness and safety of SAMe supplementation on depression severity revealed two randomized clinical trials of low risk of bias that showed no significant pooled effects for SAMe monotherapy versus placebo. One trial, also of low risk of bias, showed a significant medium short-term effect as adjunctive to …
Abstract Inherited methylation disorders are a group of rarely reported, probably largely underdiagnosed disorders affecting transmethylation processes in the metabolic pathway between methionine and homocysteine. These are methionine adenosyltransferase I/III, glycine N-methyltransferase, S adenosylhomocysteine hydrolase and adenosine kinase defi ciencies. This paper provides the first consensus recommenda tions for the diagnosis and management of methylation …
