The strengths of this study are, first, objective and well standardized measurements. Second, a randomized, double blind study that analyzes the effect of glutathione in both reduced and oxidized forms in comparison with placebo has never been conducted. Limitations are that our subjects are all female, Asian, and of certain age range.
Overall, glutathione in both forms are well tolerated. No major adverse events took place during the study period. Increases in transaminases occurred in two subjects highlight ing the fact that blood chemistry should be performed even when individuals are taking over-the-counter supplements. Nonetheless, these adverse events were transient and the blood parameters promptly returned to their normal values upon cessation of consumption. http://dx.doi.org/10.2147/CCID.S128339