Recent studies have revealed that decline in cellular nicotinamide adenine dinucleotide (NAD+ ) levels causes aging-related disorders and therapeutic approaches increasing cellular NAD+ prevent these disorders in animal models. The administration of nicotinamide mononucleotide (NMN) has been shown to mitigate aging-related dysfunctions. However, the safety of NMN in humans has remained unclear. We, therefore, conducted …
The maintenance of a low NADH/NAD+ ratio might be achieved by preserving the complex I activity from the inhibitory effects of cardio lipin peroxidation and sustained glutathionylation, for which the maintenance of high GSH/GSS ratios would be beneficial. The resultant increase in NAD+ levels might impact favorably insulin resistance in diabetes and obesity by decreasing …
The role of oxidative stress in the onset and progression of heart failure has been extensively studied. Pre-clinical studies showed promising results with various anti-oxidative strategies, but these beneficial effects did not translate into positive results in clinical studies in patients with heart failure. This might be caused by inadequate patient inclusion criteria or off-target effects …
S-adenosyl methionine (SAMe) A high-quality Cochrane review of the effectiveness and safety of the SAMe supplementation on depression severity revealed two randomized clinical trials of low risk of bias that showed no significant pooled effects for SAMe monotherapy versus placebo. One trial, also of low risk of bias, showed a significant medium short-term effect as adjunctive …
