The science of precision healthcare
JÖRG STÜLKEINSTITUT FÜR MIKROBIOLOGIE UND GENETIK, UNIVERSITÄT GÖTTINGENThe hay bacillus Bacillus subtilis has attracted scientifi c interest formore than 100 years due to its ability to form heat-stable spores as anexample of a rather simple differentiating organism. Thus, this bacterium became one of most studied model organisms. Moreover, B. subtilis is used in many biotechnological …
Bacillus subtilis – Topmodel für Forschung, Gesundheit und Biotechnologie Read More »
Alterations in metabolism in skin are accelerated by environmental stressors such as solar radiation, leading to premature aging. The impact of aging on mitochondria is of interest given their critical role for metabolic output and the finding that environmental stressors cause lowered energy output, particularly in fibroblasts where damage accumulates. To better understand these metabolic …
Nadiia Kryzhanovska, MD, PhD, reviews the literature surrounding NAD+ as a potential therapy to tackle the onset of ageing. The Magic of NAD+: A Major Player in Anti-Ageing. In 2015, KAEBERLEIN ET AL. described the primary preventive methods against age-associated diseases1. They included dietary restriction, exercise, mechanistic targets for rapamycin (mTOR) inhibitors, metformin and …
The Magic of NAD+: A Major Player in Anti-Ageing. Read More »
Mitochondrial Defects and Neuronal Loss in iPSC
and Fly Models of Parkinson’s Disease
While mitochondrial dysfunction is emerging as key in Parkinson’s disease (PD), a central question remains whether mitochondria are actual disease drivers and whether boosting mitochondrial biogenesis and function ameliorates pathology. We address these questions using patient-derived induced pluripotent stem cells and GBA-PD), the most common PD genetic risk. Patient neurons display stress responses, mitochondrial demise, and changes in NAD+ metabolism. …
Examining the Gastrointestinal and Immunomodulatory Effects of the Novel Probiotic Probiotics make up a large and growing segment of the commercial market of dietary supplements and are touted as offering a variety of human health benefits. Some of the purported positive impacts of probiotics include, but are not limited to, stabilization of the gut microbiota, …
on Intestinal Barrier Function and Inflammatory Response Strong tight junctions and curtailed inflammatory responses under stressful conditions are key for optimal digestive health. Bacillus-based probiotics are increasingly being used to maintain broilers’ health, but their mode of action is often not well-defined. In the present study we used Caco-2 cells as a model for intestinal epithelia …
Protects against a-Synuclein Aggregation in C. elegans Recent discoveries have implicated the gut microbiome in the progression and severity of Parkinson’s disease; however, how gut bacteria affect such neurodegenerative disorders remains unclear. Here, we report that the Bacillus subtilis probiotic strain PXN21 inhibits α-synuclein aggregation and clears preformed aggregates in an established Caenorhabditis elegans strains trigger the protective effect via both spores and vegetative cells, partly due …
Abstract Inherited methylation disorders are a group of rarely reported, probably largely underdiagnosed disorders affecting transmethylation processes in the metabolic pathway between methionine and homocysteine. These are methionine adenosyltransferase I/III, glycine N-methyltransferase, S adenosylhomocysteine hydrolase and adenosine kinase defi ciencies. This paper provides the first consensus recommenda tions for the diagnosis and management of methylation …
Recent studies have revealed that decline in cellular nicotinamide adenine dinucleotide (NAD+ ) levels causes aging-related disorders and therapeutic approaches increasing cellular NAD+ prevent these disorders in animal models. The administration of nicotinamide mononucleotide (NMN) has been shown to mitigate aging-related dysfunctions. However, the safety of NMN in humans has remained unclear. We, therefore, conducted …
The maintenance of a low NADH/NAD+ ratio might be achieved by preserving the complex I activity from the inhibitory effects of cardio lipin peroxidation and sustained glutathionylation, for which the maintenance of high GSH/GSS ratios would be beneficial. The resultant increase in NAD+ levels might impact favorably insulin resistance in diabetes and obesity by decreasing …