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NAD+
Bacillus subtilis – Topmodel für Forschung, Gesundheit und Biotechnologie
JÖRG STÜLKEINSTITUT FÜR MIKROBIOLOGIE UND GENETIK, UNIVERSITÄT GÖTTINGENThe hay bacillus Bacillus subtilis has attracted scientifi c interest formore than 100 years due to its ability to form heat-stable spores as anexample of a rather simple differentiating organism. Thus, this bacterium became one of most studied model organisms. Moreover, B. subtilis is used in many biotechnological …
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The Magic of NAD+: A Major Player in Anti-Ageing.
Nadiia Kryzhanovska, MD, PhD, reviews the literature surrounding NAD+ as a potential therapy to tackle the onset of ageing. The Magic of NAD+: A Major Player in Anti-Ageing. In 2015, KAEBERLEIN ET AL. described the primary preventive methods against age-associated diseases1. They included dietary restriction, exercise, mechanistic targets for rapamycin (mTOR) inhibitors, metformin and …
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The NAD+ Precursor Nicotinamide Riboside Rescues
Mitochondrial Defects and Neuronal Loss in iPSC
and Fly Models of Parkinson’s Disease
While mitochondrial dysfunction is emerging as key in Parkinson’s disease (PD), a central question remains whether mitochondria are actual disease drivers and whether boosting mitochondrial biogenesis and function ameliorates pathology. We address these questions using patient-derived induced pluripotent stem cells and GBA-PD), the most common PD genetic risk. Patient neurons display stress responses, mitochondrial demise, and changes in NAD+ metabolism. …
About NAD+
Recent studies have revealed that decline in cellular nicotinamide adenine dinucleotide (NAD+ ) levels causes aging-related disorders and therapeutic approaches increasing cellular NAD+ prevent these disorders in animal models. The administration of nicotinamide mononucleotide (NMN) has been shown to mitigate aging-related dysfunctions. However, the safety of NMN in humans has remained unclear. We, therefore, conducted …
NAD+ and insulin resistance
The maintenance of a low NADH/NAD+ ratio might be achieved by preserving the complex I activity from the inhibitory effects of cardio lipin peroxidation and sustained glutathionylation, for which the maintenance of high GSH/GSS ratios would be beneficial. The resultant increase in NAD+ levels might impact favorably insulin resistance in diabetes and obesity by decreasing …