Die Wissenschaft der Präzisionsmedizin
JÖRG STÜLKEINSTITUT FÜR MIKROBIOLOGIE UND GENETIK, UNIVERSITÄT GÖTTINGENThe hay bacillus Bacillus subtilis has attracted scientifi c interest formore than 100 years due to its ability to form heat-stable spores as anexample of a rather simple differentiating organism. Thus, this bacterium became one of most studied model organisms. Moreover, B. subtilis is used in many biotechnological …
Bacillus subtilis – Topmodel für Forschung, Gesundheit und Biotechnologie Read More »
Alterations in metabolism in skin are accelerated by environmental stressors such as solar radiation, leading to premature aging. The impact of aging on mitochondria is of interest given their critical role for metabolic output and the finding that environmental stressors cause lowered energy output, particularly in fibroblasts where damage accumulates. To better understand these metabolic …
Nadiia Kryzhanovska, MD, PhD, reviews the literature surrounding NAD+ as a potential therapy to tackle the onset of ageing. The Magic of NAD+: A Major Player in Anti-Ageing. In 2015, KAEBERLEIN ET AL. described the primary preventive methods against age-associated diseases1. They included dietary restriction, exercise, mechanistic targets for rapamycin (mTOR) inhibitors, metformin and …
The Magic of NAD+: A Major Player in Anti-Ageing. Read More »
Mitochondrial Defects and Neuronal Loss in iPSC
and Fly Models of Parkinson’s Disease
While mitochondrial dysfunction is emerging as key in Parkinson’s disease (PD), a central question remains whether mitochondria are actual disease drivers and whether boosting mitochondrial biogenesis and function ameliorates pathology. We address these questions using patient-derived induced pluripotent stem cells and GBA-PD), the most common PD genetic risk. Patient neurons display stress responses, mitochondrial demise, and changes in NAD+ metabolism. …
Examining the Gastrointestinal and Immunomodulatory Effects of the Novel Probiotic Probiotics make up a large and growing segment of the commercial market of dietary supplements and are touted as offering a variety of human health benefits. Some of the purported positive impacts of probiotics include, but are not limited to, stabilization of the gut microbiota, …
on Intestinal Barrier Function and Inflammatory Response Strong tight junctions and curtailed inflammatory responses under stressful conditions are key for optimal digestive health. Bacillus-based probiotics are increasingly being used to maintain broilers’ health, but their mode of action is often not well-defined. In the present study we used Caco-2 cells as a model for intestinal epithelia …
Protects against a-Synuclein Aggregation in C. elegans Recent discoveries have implicated the gut microbiome in the progression and severity of Parkinson’s disease; however, how gut bacteria affect such neurodegenerative disorders remains unclear. Here, we report that the Bacillus subtilis probiotic strain PXN21 inhibits α-synuclein aggregation and clears preformed aggregates in an established Caenorhabditis elegans strains trigger the protective effect via both spores and vegetative cells, partly due to …
S-adenosyl methionine (SAMe) A high-quality Cochrane review of the effectiveness and safety of SAMe supplementation on depression severity revealed two randomized clinical trials of low risk of bias that showed no significant pooled effects for SAMe monotherapy versus placebo. One trial, also of low risk of bias, showed a significant medium short-term effect as adjunctive to …
The role of oxidative stress in the onset and progression of heart failure has been extensively studied. Pre-clinical studies showed promising results with various anti-oxidative strategies, but these beneficial effects did not translate into positive results in clinical studies in patients with heart failure. This might be caused by inadequate patient inclusion criteria or offtarget …